Stem Cell Therapy
Stem Cell Therapy: Regenerative Medicine for Pain Management and Wellness
Regenerative medicine is a cutting-edge form of treatment in pain management involving biological therapies to assist in your body’s natural healing process.
Innovative Pain and Wellness uses your body’s platelets and stem cells and injects them into the damaged tissues. This has been shown to stimulate healing and speed repair for bone, muscle, joint, soft tissue and nerve injuries.
Our therapies can be used to treat a wide range of injuries and pain. You may benefit from treatment if you have a recent injury or haven’t responded well to conventional treatments, such as anti-inflammatory medications, cortisone injections, gel injections, physical therapy, surgery and rest.
Many conditions can be treated with regenerative medicine including:
- Arthritis of the joints and spine
- Pain in joints and muscle
- Muscle strains
- Ligament tears or sprains
- Tendinitis, tendinosis and tendon injuries
- Plantar fasciitis
- Meniscus tears
- Soft tissue injury
- Compression nerve injuries, such as carpal tunnel, ulnar, radial, and peroneal neuropathy
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Innovative Pain and Wellness offers several cutting edge Regenerative Medicine procedures where the body’s cells, sometimes the patient’s very own cells, are used to heal and repair their damaged tissue. These are advanced, minimally-invasive procedures that follow our philosophy of leaving no stone unturned when considering options for our patient’s plan of treatment.
These treatment options can be used alone, or in concert with other treatment options, to address the following conditions:
- Achilles tendonitis or partial tears
- Ankle sprains/ligament injury
- Hamstring tendonitis or tears
- Hip pain
- Joint pain
- Ligament sprains or tears
- Medial and Lateral Epicondylitis (golfers & tennis elbow)
- Muscle pain or injury
- Plantar Fasciitis
- Rotator Cuff tendonitis, Tendinopathy or partial tears
- Shin Splints
- Tendon injuries (Patellar Tendonitis, Quad Tendon)
- Tendonitis (Bicipital, Peroneal)
Platelet Rich Plasma Therapy (PRP) is a procedure that assists with healing and the regeneration of damaged tissue. This technique has been adopted in many fields of medicine from cosmetic surgery and dentistry to sports medicine and pain management. PRP Therapy has gained significant notoriety after many high profile professional athletes used the procedure.
Platelet-rich plasma (PRP) is a concentrated form of the platelets in your blood, obtained by processing your blood in a special centrifuge. When an injury occurs, platelets naturally begin the healing process in your body.
PRP starts by drawing a small amount of your blood. Then your blood is separated into different layers in a centrifuge which allows for the harvesting of a high concentration of platelets.
Platelets contain proteins and growth factors that the body uses in repairing injuries.
These platelets are injected directly into the site of your injury or damaged tissue. The platelets release signaling proteins that attract your body’s stem cells to the injured area. By injecting concentrated PRP into an area of concern, your body recognizes this site as a priority, working to heal more quickly and thoroughly.
Clinical data has shown that the healing factors present in platelet rich plasma may enhance and accelerate your body’s inadequate healing process.
Amniotic stem cell treatment is an injectable, flowable tissue graft derived from human placental amnion which functions as a biologic structural matrix to facilitate and enhance tissue healing and repair.
- Amniotic stem cells are a natural biologic alternative to synthetic products.
- Amniotic stem cells are derived from live, healthy, prescreened donors after live child birth.
- Donor selection and amniotic tissue recovery and processing procedures meet or exceed all applicable medical industry standards.
- Reduces fibroblast infiltration and promotes tissue reconstruction by down-regulating TGF-B receptor expression by fibroblasts.
- Contains important growth factors and proteins, which promote collagen matrix formation and cellular proliferation while minimizing the formation of scar tissue.
- Composed of collagens and structural proteins that support angiogenesis, tissue growth, and collagen production during tissue regeneration and repair.
Stem cells are a blank slate that can transform into any type of cell in the human body through a process called differentiation.
Stem cell therapy is the process of introducing these cells into areas of the body where damage has occurred, such as a sports injury or arthritic knees, where they help regenerate the entire area.
Bone Marrow Aspirate is the process of harvesting your stem cells from the rich sources found in the iliac crest of your pelvis.
During the procedure your physician will remove a sample of your stem cells and concentrate them for injection into an injured area of your body. The high concentration of stem cells works directly at the site of injury to increase the healing potential.
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Frequently Asked Questions
Your initial consultation will typically be covered by your insurance. However, many insurance companies do not cover the cost of the actual procedures, as they are currently considered investigational. The overall cost of treatment will depend on the type of treatment recommended and whether one or multiple treatment rounds are necessary.
Patients may require one to three treatments and typically experience improvement in pain and mobility within 4-6 weeks with continued improvement over 3 months after procedure. Our goal is to have an 80-90% improvement in pain and function.
This is an outpatient procedure that results in little down time for the patient. Typically, we do suggest patients rest after the procedure, but they can return to normal activities within about three days.
There is some discomfort in obtaining the bone marrow aspirate and fat tissue that is minimalized by using a local anesthetic. A varying degree of discomfort is also associated with the initial injection of a local anesthetic at the injured site. However, there should be minimal pain during the administration of the PRP or BMA. Usually the anesthetic lasts for a couple of hours. You may experience significant discomfort for the first 24 to 72 hours during the healing process. They physician will prescribe a pain medication to help manage your discomfort. Tylenol can also be used.
This decision, made by the physician, is individualized and based on personal experience as well as the published research of other practitioners who perform similar procedures around the world. Depending on the severity of the injury, and/or disease, some patients require PRP alone, some BMA alone, and others fat grafting along with the PRP/BMA.
The physician will use ultrasound guidance for targeted placement of your body’s platelets/stem cells into the damaged tissue. The sample can be injected into an injured tendon, ligament, nerve, muscle, bone or joint.
Adipose Derived Stem Cells (ADSC), or fat tissue, is obtained using a special tool at a site on the body where fat is easily stored. Fat has a very high concentration of stem cells and works wonderfully as the scaffolding for the PRP or BMA injections to activate your healing cascade.
The most common side effect is post-treatment discomfort. For the first 72 hours, some patients may experience low grade fevers, swelling at the site of the injection, body aches and fatigue. Specific risks and benefits for each treatment of interest will be discussed at the time of the initial consultation.
If a patient responds well to the treatment, physician experience has shown that most will achieve improved pain and function for a period of 3-7 years from the initial stem cell procedure. Here again, success and longevity of the treatment depend on the severity of the knee condition and the individual’s healing potential.
Success of the treatment depends on the severity of the knee condition and each patient’s own healing potential. Most respond well to stem cell treatments and report significant improvement in their mobility and ability to return to activities they enjoy. Many of our patients have had dramatic recoveries from conditions such as arthritis, regaining the ability to walk, dance, run, climb, and/or ski again without pain. At very least, the vast majority of patients report a reduction in the pain they had been having. The success rate of your specific condition will be assessed at your initial consultation once we have a chance to review your injury.
Patients may feel soreness for 3-5 days but are generally able to walk and do their normal activities. Most patients will start home exercises or physical therapy about 2 weeks after the procedure to work on range of motion, balance and strength. Patients typically get back into sports and exercise at 4-6 weeks out from the procedure.
The treatment is done in an office setting. No general anesthesia is required. We only use local anesthesia at the sites of the injections. Carefully guided ultrasound is used to find a sample of stem cells or platelets. Typically, they are drawn from bone marrow in the pelvis bone and fat tissue from the love handles. There is little pain during the procedure itself.
The sample is then concentrated in a stem cell centrifuge. Using ultrasound to guide the procedure, the concentrated stem cells are injected at the site of the injured joint. It’s similar to a steroid injection. All of this is done in one visit, takes a little more than an hour, and you walk out of the office.
Stem cells are the very basic cells that have not yet decided what final tissue that they will become – such as a cartilage cell, bone cell, muscle cell, etc. We all carry stem cells throughout our bodies that act as the body’s “repairmen.” There are several different kinds of stem cells. Mesenchymal stem cells (MSC) are the type that we use in orthopedic treatments. MSC’s have the strongest potential to repair muscle, bone, joint and soft tissue injuries. These cells have the ability to self-replicate, reduce inflammation and differentiate into cartilage, bone, muscle and fat cells to help the body regenerate the lost tissue in the injured area.
When these cells are placed in an injured environment, such as an arthritic knee, they are more likely to turn into the cells that the body needs. In the case of arthritis, the cells will recognize that there are cartilage injuries and help to repair the cartilage defects. Also with arthritis, there is an imbalance between the cartilage cell’s ability to build up or turn over normal cartilage because of the increased inflammation inside the knee. The stem cells help to change the inflammatory state of the knee, which not only helps to rebuild cartilage, but makes the knee significantly less painful.
Journal Articles and Research on Regenerative Medicine
Concentrated Bone Marrow Aspirate for the Treatment of Chondral Injuries and Osteoarthritis of the Knee A Systematic Review of Outcomes – Read Full Article – ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
Clinical Outcome of Bone Marrow Concentrate in Knee Osteoarthritis – Read Full Article – JOURNAL of PROLOTHERAPY
Emerging Applications of Stem Cell and Regenerative Medicine to Sports Injuries – Read Full Article – JOURNAL for ORTHOPAEDIC SPORTS MEDICINE
Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain Through 12 Months – Read Full Article – STEM CELLS
Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-Articular Orthobiologic for Cartilage Disease – Read Full Article – THE PHYSICIAN AND SPORTS MEDICINE
Clinical outcome of autologous bone marrow aspirates concentrate (BMAC) injection in degenerative arthritis of the knee – Read Full Article – EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY & TRAUMATOLOGY
Injection of Bone Marrow Concentrate for Refractory Tennis Elbow – Read Full Article – SAUDI JOURNAL OF SPORTS MEDICINE
Increased Knee Cartilage Volume in Degenerative Joint Disease using Percutaneously Implanted, Autologous Mesenchymal Stem Cells – Read Full Article – PAIN PHYSICIAN
Percutaneous Autologous Bone Marrow Injection in the Treatment of Distal Meta-diaphyseal Tibial Nonunions and Delayed Unions – Read Full Article – JOURNAL OF ORTHOPAEDIC TRAUMA